Fluge and Mella used an expensive bit of kit called the Seahorse analyser, which measures glycolysis through the lactate production and mitochondrial activity through changes in oxygen levels.
They tested normal healthy muscle cells that had been grown in the lab. But they added to those cells serum taken from either ME/CFS patients or healthy controls. Serum is the fluid left over after blood has clotted and it contains small molecules and other soluble substances.
They have data for 12 people with ME/CFS and 12 healthy controls, a relatively small sample.What they found was, surprisingly, that the muscle cells produced more lactate and burned more oxygen when they were incubated with ME/CFS serum than when incubated in serum from healthy controls. And the effect was particularly strong when the cells were made to work hard.
More evidence that our reliance on cars is killing us.
If you want to be as healthy as possible, there are no treadmills or weight machines required. Don’t just take my word for it—look to the longest-lived people in the world for proof.
People in the world’s Blue Zones—the places around the world with the highest life expectancy—don’t pump iron, run marathons or join gyms.
Instead, they live in environments that constantly nudge them into moving without even thinking about it. This means that they grow gardens, walk throughout the day, and minimize mechanical conveniences for house and yard work.
In fact, Blue Zones researchers determined that routine natural movement is one of the most impactful ways to increase your life span, and a common habit among the world’s longest-lived populations.
I was searching for stuff on my computer tonight when I came across a diary entry I created back on my 28th birthday, 21 Jan 1997. I had started journaling then mainly because I had started having trouble with my memory. It is also why I began this blog, as I’ve said before.
This entry is from a time when I was young, single, fit, and supposedly at the top of my game, yet I was deeply concerned about my future. I post it today to remind myself of just how long I’ve been dealing with Gulf War Illness.
It has been three decades of pain and frustration but I am still here.
Looking at the old clock on the wall I see that I’ve just turned 28 years old. Here I am sitting at my keyboard on my 28th birthday, all alone save for a lazy cat. I didn’t feel like staying at the party because I’m feeling down, so I guess I really didn’t have to be alone. I can’t talk to those guys about what’s bothering me because they couldn’t relate. There are very few people who could. But the party was getting my down because I couldn’t seem to jump-start myself into the conversation, and I became alarmed at this inability to speak.
I woke up early this morning, restless after putting Rocket down last night, and decided a walk would be good therapy. I stepped out of the house and began my usual route around the neighborhood.
As I approached a stretch of Plainview Avenue that’s bordered by cars on both sides and a construction dumpster on one side, a car passed me from behind without incident.
But a minute later I heard another car approaching from behind. Instantly I was filled with alarm. I was walking along the farthest left edge of the road that I could be but something didn’t feel right.
“Please don’t kill me,” I thought firmly in my head, not pausing for a moment to wonder why something so ridiculous would occur to me.
The car, an off-white Altima-type with California tags, came up quickly, taking up much of the left lane. It passed by so close to me that the driver’s side mirror actually gently brushed against my jacket.
If I had taken just one step to my right I would be seriously injured or dead right now. I’m so thankful for my spidey sense.
Packing for a two-week trip through the Arctic on a nuclear icebreaking ship sounds like an extraordinary endeavor, but it’s all part of the job for Dr. Joanne Feldman, Assistant Clinical Professor at UCLA’s Department of Emergency Medicine and a polar expedition physician with Quark Expeditions. Dr. Feldman, better known as Dr. Jo, has become an expert in motion sickness treatment through many seasons of braving the high seas on expedition ships to both the Arctic and Antarctic; and her specialty in wilderness emergency medicine and experience as a physician with the U.S. Antarctic Program at Palmer Station primed her for the challenges of experiencing life at the extremes. For the less seasoned on the seas, Dr. Jo is a resource as well as a potentially lifesaving presence. Condé Nast Traveler? spoke with her onboard the ship 50 Years of Victory as it powered through ice near the North Pole:
William Whitt suffered violent diarrhea for days. But once he began vomiting blood, he knew it was time to rush to the hospital. His body swelled up so much that his wife thought he looked like the Michelin Man, and on the inside, his intestines were inflamed and bleeding.
For four days last spring, doctors struggled to control the infection that was ravaging Whitt, a father of three in western Idaho. The pain was excruciating, even though he was given opioid painkillers intravenously every 10 minutes for days.
His family feared they would lose him.
“I was terrified. I wouldn’t leave the hospital because I wasn’t sure he was still going to be there when I got back,” said Whitt’s wife, Melinda.
Whitt and his family were baffled: How could a healthy 37-year-old suddenly get so sick? While he was fighting for his life, the U.S. Centers for Disease Control and Prevention quizzed Whitt, seeking information about what had sickened him.
Finally, the agency’s second call offered a clue: “They kept drilling me about salad,” Whitt recalled. Before he fell ill, he had eaten two salads from a pizza shop.
The gut has made a sudden rise to prominence as an arbiter of overall health. It’s well established that gut bacteria, also known as the microbiome, can influence digestion, allergies and metabolism. But these microbes’ reach may extend much further – into the brain. Conditions including depression and anxiety are now being linked to the digestive system.
The brain may be one of the most complex objects known to humankind, but science has suggested the digestive system is of equal importance, especially when it comes to our emotional health. Your gut is teeming with trillions of bacteria, making up what’s known as the microbiome. Collectively weighing up to two kilograms (heavier than the average brain), the microbiome plays a vital role in your health, breaking down food, supporting immunity and, perhaps surprisingly, affecting mood. Nutritionist Rebecca Pilkington believes keeping the microbiome balanced is the key to optimal physical and mental health. “If your gut is out of whack,” she says, “this can lead to inflammation, believed to be one of the biggest causes of depression.”
Great investigation by ProPublica into the dangers of Teflon and Scotchgard.
The chemicals once seemed near magical, able to repel water, oil and stains.
By the 1970s, DuPont and 3M had used them to develop Teflon and Scotchgard, and they slipped into an array of everyday products, from gum wrappers to sofas to frying pans to carpets. Known as perfluoroalkyl substances, or PFAS, they were a boon to the military, too, which used them in foam that snuffed out explosive oil and fuel fires.
It’s long been known that, in certain concentrations, the compounds could be dangerous if they got into water or if people breathed dust or ate food that contained them. Tests showed they accumulated in the blood of chemical factory workers and residents living nearby, and studies linked some of the chemicals to cancers and birth defects.
Now two new analyses of drinking water data and the science used to analyze it make clear the Environmental Protection Agency and the Department of Defense have downplayed the public threat posed by these chemicals. Far more people have likely been exposed to dangerous levels of them than has previously been reported because contamination from them is more widespread than has ever been officially acknowledged.
Here’s a frightening, detailed account of what it’s like to become a victim of the mystery sonic/microwave attacks that have plagued our diplomatic corps.
WASHINGTON — Alone in her bed in a sprawling Chinese metropolis, Catherine Werner was jolted awake one night by a pulsing, humming sound. It seemed to be coming from a specific direction.
Perhaps the A.C. unit in her upscale Guangzhou apartment was malfunctioning, the American diplomat thought. But at the same moment, she also noticed intense pressure in her head.
The sounds and sensations returned, night after night, for months. When Werner’s health began declining in late 2017 — vomiting, headaches, loss of balance — she brushed it off at first, thinking China’s polluted air and water were getting to her.
It wasn’t until months later — after her mother, Laura Hughes, grew alarmed, flew in from the U.S. and then got sick, too — that Werner was medevaced from China back to the States. Doctors at the University of Pennsylvania found a vision disorder, a balance disorder and an “organic brain injury” — diagnoses similar to those of 26 U.S. diplomats and spies in Cuba who started hearing strange sounds and falling ill in late 2016.
The recommended amount of sleep an adult needs is between seven and nine hours each night. But for many, finding this time isn’t the problem–it’s falling asleep once your head hits the pillow. I’m one of those people who occasionally has this problem, and in the past have tried everything from meditation to medication. But for the last four weeks, I tried something different–and it’s something worth trying if you have sleep problems.
Recently, an old method used by the U.S. Army to help soldiers fall to sleep in less than ideal conditions (like battlefields) has resurfaced. The Independent says the technique was first described in a book from 1981 called Relax and Win: Championship Performance by Lloyd Bud Winter.
In the book, Winter describes the technique designed by the U.S. Army to make sure soldiers didn’t make mistakes due to grogginess. The technique apparently sends you off to sleep within two minutes.