Life as we know it has changed in an astonishingly quick moment. Last week it was fairly normal when it looked like China might be able to contain the virus but then panic set in across the country. Sports leagues like the NBA, NCAA, ACC, and NHL canceled their games. Raleigh’s Saint Patrick’s Day parade was called off. Then Wake County Public Schools decided last Friday to not count absences before turning around on Saturday and closing schools. A week ago I worked my first day at home and have not been back to the office except for a brief time Saturday to retrieve the plants off my desk.
We are doing what is termed “social distancing,” where we interact with as few people as possible. The kids are at home, Kelly and I are at home and we have largely given up any trips outside of the house except for dire emergencies. It is frightening and surreal. In an instant life has changed drastically.
It has been day three of our all being at home. Our home is big enough that we can find our own corners and not disturb each other. When we’re sharing our home office, Kelly has complained about how loudly I chew gum (narrator: it’s not that loud). Spirits are high now but the realization is setting in that this will not be over any time soon. We may have to shelter in place like this for months.
The saving grace is that we are not strictly confined to our homes. At least, not yet. We can go for drives, walks, bike rides, dog walks. Whatever. We are just encouraged to maintain that six-foot distance experts suggest will keep us safe from getting the SARS-CoV-2 coronavirus that causes COVID-19.
The start of the fateful sledding run
I spent this past week at the Veterans Administration’s War-Related Illnesses and Injuries Center (WRIISC), getting examined to figure out the strange health issues I’ve had since leaving the Navy (more on that later).
One issue I discussed with them has bothered me for the past few years.I’ve had a numbness that has developed along my right quadricep. It’s icy-cold sensation can wake me from a deep sleep and is quite aggravating. They asked me if I could recall any injury I may have had to my lower back.
At the time I could think of none. but when pondering it this morning the answer came to me and it is decidedly not war-related. Instead, it’s the long-delayed consequences from an injury I received from snow sledding with the family.
They started out studying the immune response to brain tumors in children. But what they found may not only stop tumors from growing, but halt Alzheimer’s disease as well. Scientists at St. Jude Children’s Research Hospital—the only National Cancer Institute-designated Comprehensive Cancer Center devoted solely to children—have discovered a pathway that prevents the buildup of a toxic protein associated with Alzheimer’s disease. The findings offer a possible new approach to treatment of Alzheimer’s and cancer.
Researchers of the study—published this month in the journal Cell—named the pathway LC3-associated endocytosis or LANDO. They hope to now find compounds that will allow them to restore functioning of the pathway to treat Alzheimer’s disease or block it to treat malignant tumors.
Source: Newly Discovered Cellular Pathway May Mean New Approach For How We Treat Alzheimer’s and Cancer
For the past few years I’ve been getting a chip in my front tooth patched by my dentist. This patch will last anywhere between 8 months to as short as one hour before it pops off and I have to get it done again. I’m not a fan of the look of this chipped tooth but I can’t keep getting it patched, either. My dentist, recommended I get orthodontics to help keep my teeth from smacking together and dislodging the patch.
The orthodontist recommended by my dentist put a hefty price tag on moving my teeth and I just couldn’t justify the cost. I put that on hold before I checked out Smile Direct Club (SDC). SDC would use the same invisible aligners (InvisAlign) that the orthodontist would use but the cost would be less than two-thirds the price. The downside is I wouldn’t receive personal care from an orthodontist. I decided to go for it, since I have had three years of orthodontics experience as a teenager and know what to expect.
So far, it’s been so good. I put in my first aligners a week ago Saturday and began my second one this past Saturday. My teeth ached a bit for most of the first week but by that Wednesday I felt comfortable enough wearing them that I didn’t mind them anymore. There’s no question that my teeth have shifted in the 9 days I’ve worn the aligners, so I have no doubt that they’re working. And I’ve become a bit obsessed with wearing them.
Fluge and Mella used an expensive bit of kit called the Seahorse analyser, which measures glycolysis through the lactate production and mitochondrial activity through changes in oxygen levels.
They tested normal healthy muscle cells that had been grown in the lab. But they added to those cells serum taken from either ME/CFS patients or healthy controls. Serum is the fluid left over after blood has clotted and it contains small molecules and other soluble substances.
They have data for 12 people with ME/CFS and 12 healthy controls, a relatively small sample.What they found was, surprisingly, that the muscle cells produced more lactate and burned more oxygen when they were incubated with ME/CFS serum than when incubated in serum from healthy controls. And the effect was particularly strong when the cells were made to work hard.
Source: Something in the blood – ME/CFS Research Review
More evidence that our reliance on cars is killing us.
If you want to be as healthy as possible, there are no treadmills or weight machines required. Don’t just take my word for it—look to the longest-lived people in the world for proof.
People in the world’s Blue Zones—the places around the world with the highest life expectancy—don’t pump iron, run marathons or join gyms.
Instead, they live in environments that constantly nudge them into moving without even thinking about it. This means that they grow gardens, walk throughout the day, and minimize mechanical conveniences for house and yard work.
In fact, Blue Zones researchers determined that routine natural movement is one of the most impactful ways to increase your life span, and a common habit among the world’s longest-lived populations.
Source: The healthiest people in the world don’t go to the gym — Quartzy
I was searching for stuff on my computer tonight when I came across a diary entry I created back on my 28th birthday, 21 Jan 1997. I had started journaling then mainly because I had started having trouble with my memory. It is also why I began this blog, as I’ve said before.
This entry is from a time when I was young, single, fit, and supposedly at the top of my game, yet I was deeply concerned about my future. I post it today to remind myself of just how long I’ve been dealing with Gulf War Illness.
It has been three decades of pain and frustration but I am still here.
Looking at the old clock on the wall I see that I’ve just turned 28 years old. Here I am sitting at my keyboard on my 28th birthday, all alone save for a lazy cat. I didn’t feel like staying at the party because I’m feeling down, so I guess I really didn’t have to be alone. I can’t talk to those guys about what’s bothering me because they couldn’t relate. There are very few people who could. But the party was getting my down because I couldn’t seem to jump-start myself into the conversation, and I became alarmed at this inability to speak.
I woke up early this morning, restless after putting Rocket down last night, and decided a walk would be good therapy. I stepped out of the house and began my usual route around the neighborhood.
As I approached a stretch of Plainview Avenue that’s bordered by cars on both sides and a construction dumpster on one side, a car passed me from behind without incident.
But a minute later I heard another car approaching from behind. Instantly I was filled with alarm. I was walking along the farthest left edge of the road that I could be but something didn’t feel right.
“Please don’t kill me,” I thought firmly in my head, not pausing for a moment to wonder why something so ridiculous would occur to me.
The car, an off-white Altima-type with California tags, came up quickly, taking up much of the left lane. It passed by so close to me that the driver’s side mirror actually gently brushed against my jacket.
If I had taken just one step to my right I would be seriously injured or dead right now. I’m so thankful for my spidey sense.
Packing for a two-week trip through the Arctic on a nuclear icebreaking ship sounds like an extraordinary endeavor, but it’s all part of the job for Dr. Joanne Feldman, Assistant Clinical Professor at UCLA’s Department of Emergency Medicine and a polar expedition physician with Quark Expeditions. Dr. Feldman, better known as Dr. Jo, has become an expert in motion sickness treatment through many seasons of braving the high seas on expedition ships to both the Arctic and Antarctic; and her specialty in wilderness emergency medicine and experience as a physician with the U.S. Antarctic Program at Palmer Station primed her for the challenges of experiencing life at the extremes. For the less seasoned on the seas, Dr. Jo is a resource as well as a potentially lifesaving presence. Condé Nast Traveler? spoke with her onboard the ship 50 Years of Victory as it powered through ice near the North Pole:
Source: The NASA Space Treatment That Will Cure Your Seasickness – Condé Nast Traveler
William Whitt suffered violent diarrhea for days. But once he began vomiting blood, he knew it was time to rush to the hospital. His body swelled up so much that his wife thought he looked like the Michelin Man, and on the inside, his intestines were inflamed and bleeding.
For four days last spring, doctors struggled to control the infection that was ravaging Whitt, a father of three in western Idaho. The pain was excruciating, even though he was given opioid painkillers intravenously every 10 minutes for days.
His family feared they would lose him.
“I was terrified. I wouldn’t leave the hospital because I wasn’t sure he was still going to be there when I got back,” said Whitt’s wife, Melinda.
Whitt and his family were baffled: How could a healthy 37-year-old suddenly get so sick? While he was fighting for his life, the U.S. Centers for Disease Control and Prevention quizzed Whitt, seeking information about what had sickened him.
Finally, the agency’s second call offered a clue: “They kept drilling me about salad,” Whitt recalled. Before he fell ill, he had eaten two salads from a pizza shop.
Source: 5 people died from eating lettuce, but Trump’s FDA still won’t make farms test water for bacteriaReveal