They started out studying the immune response to brain tumors in children. But what they found may not only stop tumors from growing, but halt Alzheimer’s disease as well. Scientists at St. Jude Children’s Research Hospital—the only National Cancer Institute-designated Comprehensive Cancer Center devoted solely to children—have discovered a pathway that prevents the buildup of a toxic protein associated with Alzheimer’s disease. The findings offer a possible new approach to treatment of Alzheimer’s and cancer.
Researchers of the study—published this month in the journal Cell—named the pathway LC3-associated endocytosis or LANDO. They hope to now find compounds that will allow them to restore functioning of the pathway to treat Alzheimer’s disease or block it to treat malignant tumors.
For the past few years I’ve been getting a chip in my front tooth patched by my dentist. This patch will last anywhere between 8 months to as short as one hour before it pops off and I have to get it done again. I’m not a fan of the look of this chipped tooth but I can’t keep getting it patched, either. My dentist, recommended I get orthodontics to help keep my teeth from smacking together and dislodging the patch.
The orthodontist recommended by my dentist put a hefty price tag on moving my teeth and I just couldn’t justify the cost. I put that on hold before I checked out Smile Direct Club (SDC). SDC would use the same invisible aligners (InvisAlign) that the orthodontist would use but the cost would be less than two-thirds the price. The downside is I wouldn’t receive personal care from an orthodontist. I decided to go for it, since I have had three years of orthodontics experience as a teenager and know what to expect.
So far, it’s been so good. I put in my first aligners a week ago Saturday and began my second one this past Saturday. My teeth ached a bit for most of the first week but by that Wednesday I felt comfortable enough wearing them that I didn’t mind them anymore. There’s no question that my teeth have shifted in the 9 days I’ve worn the aligners, so I have no doubt that they’re working. And I’ve become a bit obsessed with wearing them.
Fluge and Mella used an expensive bit of kit called the Seahorse analyser, which measures glycolysis through the lactate production and mitochondrial activity through changes in oxygen levels.
They tested normal healthy muscle cells that had been grown in the lab. But they added to those cells serum taken from either ME/CFS patients or healthy controls. Serum is the fluid left over after blood has clotted and it contains small molecules and other soluble substances.
They have data for 12 people with ME/CFS and 12 healthy controls, a relatively small sample.What they found was, surprisingly, that the muscle cells produced more lactate and burned more oxygen when they were incubated with ME/CFS serum than when incubated in serum from healthy controls. And the effect was particularly strong when the cells were made to work hard.
More evidence that our reliance on cars is killing us.
If you want to be as healthy as possible, there are no treadmills or weight machines required. Don’t just take my word for it—look to the longest-lived people in the world for proof.
People in the world’s Blue Zones—the places around the world with the highest life expectancy—don’t pump iron, run marathons or join gyms.
Instead, they live in environments that constantly nudge them into moving without even thinking about it. This means that they grow gardens, walk throughout the day, and minimize mechanical conveniences for house and yard work.
In fact, Blue Zones researchers determined that routine natural movement is one of the most impactful ways to increase your life span, and a common habit among the world’s longest-lived populations.
I was searching for stuff on my computer tonight when I came across a diary entry I created back on my 28th birthday, 21 Jan 1997. I had started journaling then mainly because I had started having trouble with my memory. It is also why I began this blog, as I’ve said before.
This entry is from a time when I was young, single, fit, and supposedly at the top of my game, yet I was deeply concerned about my future. I post it today to remind myself of just how long I’ve been dealing with Gulf War Illness.
It has been three decades of pain and frustration but I am still here.
Looking at the old clock on the wall I see that I’ve just turned 28 years old. Here I am sitting at my keyboard on my 28th birthday, all alone save for a lazy cat. I didn’t feel like staying at the party because I’m feeling down, so I guess I really didn’t have to be alone. I can’t talk to those guys about what’s bothering me because they couldn’t relate. There are very few people who could. But the party was getting my down because I couldn’t seem to jump-start myself into the conversation, and I became alarmed at this inability to speak.
I woke up early this morning, restless after putting Rocket down last night, and decided a walk would be good therapy. I stepped out of the house and began my usual route around the neighborhood.
As I approached a stretch of Plainview Avenue that’s bordered by cars on both sides and a construction dumpster on one side, a car passed me from behind without incident.
But a minute later I heard another car approaching from behind. Instantly I was filled with alarm. I was walking along the farthest left edge of the road that I could be but something didn’t feel right.
“Please don’t kill me,” I thought firmly in my head, not pausing for a moment to wonder why something so ridiculous would occur to me.
The car, an off-white Altima-type with California tags, came up quickly, taking up much of the left lane. It passed by so close to me that the driver’s side mirror actually gently brushed against my jacket.
If I had taken just one step to my right I would be seriously injured or dead right now. I’m so thankful for my spidey sense.
Packing for a two-week trip through the Arctic on a nuclear icebreaking ship sounds like an extraordinary endeavor, but it’s all part of the job for Dr. Joanne Feldman, Assistant Clinical Professor at UCLA’s Department of Emergency Medicine and a polar expedition physician with Quark Expeditions. Dr. Feldman, better known as Dr. Jo, has become an expert in motion sickness treatment through many seasons of braving the high seas on expedition ships to both the Arctic and Antarctic; and her specialty in wilderness emergency medicine and experience as a physician with the U.S. Antarctic Program at Palmer Station primed her for the challenges of experiencing life at the extremes. For the less seasoned on the seas, Dr. Jo is a resource as well as a potentially lifesaving presence. Condé Nast Traveler? spoke with her onboard the ship 50 Years of Victory as it powered through ice near the North Pole:
William Whitt suffered violent diarrhea for days. But once he began vomiting blood, he knew it was time to rush to the hospital. His body swelled up so much that his wife thought he looked like the Michelin Man, and on the inside, his intestines were inflamed and bleeding.
For four days last spring, doctors struggled to control the infection that was ravaging Whitt, a father of three in western Idaho. The pain was excruciating, even though he was given opioid painkillers intravenously every 10 minutes for days.
His family feared they would lose him.
“I was terrified. I wouldn’t leave the hospital because I wasn’t sure he was still going to be there when I got back,” said Whitt’s wife, Melinda.
Whitt and his family were baffled: How could a healthy 37-year-old suddenly get so sick? While he was fighting for his life, the U.S. Centers for Disease Control and Prevention quizzed Whitt, seeking information about what had sickened him.
Finally, the agency’s second call offered a clue: “They kept drilling me about salad,” Whitt recalled. Before he fell ill, he had eaten two salads from a pizza shop.
The gut has made a sudden rise to prominence as an arbiter of overall health. It’s well established that gut bacteria, also known as the microbiome, can influence digestion, allergies and metabolism. But these microbes’ reach may extend much further – into the brain. Conditions including depression and anxiety are now being linked to the digestive system.
The brain may be one of the most complex objects known to humankind, but science has suggested the digestive system is of equal importance, especially when it comes to our emotional health. Your gut is teeming with trillions of bacteria, making up what’s known as the microbiome. Collectively weighing up to two kilograms (heavier than the average brain), the microbiome plays a vital role in your health, breaking down food, supporting immunity and, perhaps surprisingly, affecting mood. Nutritionist Rebecca Pilkington believes keeping the microbiome balanced is the key to optimal physical and mental health. “If your gut is out of whack,” she says, “this can lead to inflammation, believed to be one of the biggest causes of depression.”
Great investigation by ProPublica into the dangers of Teflon and Scotchgard.
The chemicals once seemed near magical, able to repel water, oil and stains.
By the 1970s, DuPont and 3M had used them to develop Teflon and Scotchgard, and they slipped into an array of everyday products, from gum wrappers to sofas to frying pans to carpets. Known as perfluoroalkyl substances, or PFAS, they were a boon to the military, too, which used them in foam that snuffed out explosive oil and fuel fires.
It’s long been known that, in certain concentrations, the compounds could be dangerous if they got into water or if people breathed dust or ate food that contained them. Tests showed they accumulated in the blood of chemical factory workers and residents living nearby, and studies linked some of the chemicals to cancers and birth defects.
Now two new analyses of drinking water data and the science used to analyze it make clear the Environmental Protection Agency and the Department of Defense have downplayed the public threat posed by these chemicals. Far more people have likely been exposed to dangerous levels of them than has previously been reported because contamination from them is more widespread than has ever been officially acknowledged.