Goldman asks: ‘Is curing patients a sustainable business model?’

When I first confronted my GERD stomach issues a few decades ago I had a choice: I could simply take an antacid pill each day for life or I could get surgery to fix it. The pill would’ve been easy, painless, and relatively inexpensive but I chose the surgery simply because I didn’t want to be dependent on Big Pharma.

This Golden Sachs analyst’s remarkable candor shows, in a nutshell, what’s wrong with a capitalistic health care system. What’s good for the patient is not always good for the investor. In fact, pretty frequently it’s not.

If you had any illusions about the true motivation of the medical industry you should now know the truth.

Wall Street greed is often why we can’t have nice things.

Goldman Sachs analysts attempted to address a touchy subject for biotech companies, especially those involved in the pioneering “gene therapy” treatment: cures could be bad for business in the long run.

“Is curing patients a sustainable business model?” analysts ask in an April 10 report entitled “The Genome Revolution.”

“The potential to deliver ‘one shot cures’ is one of the most attractive aspects of gene therapy, genetically-engineered cell therapy and gene editing. However, such treatments offer a very different outlook with regard to recurring revenue versus chronic therapies,” analyst Salveen Richter wrote in the note to clients Tuesday. “While this proposition carries tremendous value for patients and society, it could represent a challenge for genome medicine developers looking for sustained cash flow.”

Source: Goldman asks: ‘Is curing patients a sustainable business model?’

Pahrump-based radio host Art Bell dies at 72 – Las Vegas Review-Journal

North Carolina native, talk show pioneer, and fellow explorer Art Bell has passed away, or as we in the amateur radio field say, W6OBB is now a “silent key.”

I started listening to Art Bell’s Coast to Coast show back around 1995. Much of what I heard was off-the-wall nonsense but some of it was truly amazing. Life-changing amazing, in fact.

He was always a gentleman on the airwaves, no matter whom was his guest. In the depths of those dark nights you always felt like you had a friend out there, somewhere in the desert of Nevada.

Thanks for all the stimulating conversation and for shining a light on some of the most interesting topics imaginable.

He was awake when most of the country was asleep, cultivating a loyal following while sharing his fascination with the unexplained on his nighttime paranormal-themed show.

For the better part of two decades, longtime late-night radio personality Art Bell was his own producer, engineer and host of his show, “Coast to Coast AM.” He later launched his own satellite radio program from his Pahrump home after retiring from full-time hosting duties in 2003.

On the airwaves, Bell captivated listeners with his fascination for the unexplained, such as UFOs, alien abductions and crop circles. He died Friday at his home at the age of 72.

“As he begins his journey on the ‘other side,’ we take solace in the hope that he is now finding out all of the answers to the mysteries he pursued for so many nights with all of us,” Coast to Coast said in a statement Saturday.

Source: Pahrump-based radio host Art Bell dies at 72 – Las Vegas Review-Journal

NFS Exports And XFS’s inode64 Mount Option – mmacleod.ca

I recently formatted my home NAS with the XFS filesystem, then was mystified when some NFS exports worked fine while others didn’t. It turns out it’s an XFS quirk and needs a tweak to the /etc/exports file, as detailed in this blog post below.

I fixed it by adding fsid=1, fsid=2, … to the export options of each share in /etc/exports so that NFS could individually identify them. Kind of a bother but it works!

I recently turned up a new RAID array and plopped an XFS filesystem down on it. I didn’t bother setting any specific tunings when I created the filesystem. However I couldn’t for the life of me export any subdirectories from the volume over NFS. Local access was fine and I could export via netatalk and samba.On the server I saw messages like this in the logs:

Feb 14 13:08:43 monolith rpc.mountd[3092]: authenticated mount request from 192.168.1.50:1003 for /mnt/music (/mnt/music)Feb 14 13:08:57 monolith rpc.mountd[3092]: authenticated mount request from 192.168.1.50:1002 for /opt/music (/opt/music)Feb 14 13:15:19 monolith rpc.mountd[3092]: authenticated mount request from 192.168.1.20:717 for /mnt/music (/mnt/music)Feb 14 13:15:20 monolith rpc.mountd[3092]: authenticated mount request from 192.168.1.20:1001 for /mnt/music (/mnt/music)Feb 14 13:15:22 monolith rpc.mountd[3092]: authenticated mount request from 192.168.1.20:1002 for /mnt/music (/mnt/music)Feb 14 13:15:26 monolith rpc.mountd[3092]: authenticated mount request from 192.168.1.20:801 for /mnt/music (/mnt/music)Feb 14 13:15:34 monolith rpc.mountd[3092]: authenticated mount request from 192.168.1.20:967 for /mnt/music (/mnt/music)Feb 14 13:15:44 monolith rpc.mountd[3092]: authenticated mount request from 192.168.1.20:794 for /mnt/music (/mnt/music)Feb 14 13:15:54 monolith rpc.mountd[3092]: authenticated mount request from 192.168.1.20:855 for /mnt/music (/mnt/music)Feb 14 13:16:04 monolith rpc.mountd[3092]: authenticated mount request from 192.168.1.20:863 for /mnt/music (/mnt/music)Feb 14 13:16:14 monolith rpc.mountd[3092]: authenticated mount request from 192.168.1.20:932 for /mnt/music (/mnt/music)Feb 14 13:16:24 monolith rpc.mountd[3092]: authenticated mount request from 192.168.1.20:830 for /mnt/music (/mnt/music)

On the client I would get two different behaviours, depending on whether it was NFSv4 or NFSv3 that was being used. With NFSv4 it would mount the directory, but any attempt to read from it would give a ‘Stale NFS handle’ error:

root:~# mount -t nfs -v 192.168.1.10:/mnt/music /mnt/mount.nfs: timeout set for Fri Feb 14 16:49:39 2014mount.nfs: trying text-based options 'vers=4,addr=192.168.1.10,clientaddr=192.168.1.20'root:~# ls /mnt/ls: cannot open directory /mnt/: Stale NFS file handle

Source: NFS Exports And XFS’s inode64 Mount Option – mmacleod.ca